The findings indicated that a fasting mimicking diet is safe and effective as an adjunct to chemotherapy in women with early breast cancer. Study results from the phase 2 DIRECT study are the first to indicate that a fasting mimicking diet FMD is safe and effective as an adjunct to chemotherapy in women with early breast cancer. The findings, published in Nature Communications, build upon preclinical evidence suggesting that fasting and FMDs prior to chemotherapymay have a beneficial effect on both the efficacy of a wide variety of cancer therapies and on the reduction of the side effects caused by various cancer treatments. With an FMD, you get to eat, so you’re not too hangry, but your cells still respond as if you’re strictly fasting. Of the 65 patients who received FMD, 53 In the regular diet group, 5 7. The overall pCR rate was The radiologically complete or partial response, as measured by MRI or ultrasound before surgery, occurred approximately 3 times more often in the FMD group compared to the control group in univariate OR, 2. Similarly, the proportion of patients with stable or progressive disease was 2. Moreover, the percentage of patients who discontinued chemotherapy did not significantly differ between either group Importantly though, while side effects were similar in both arms, patients in the FMD arm did not receive dexamethasone before the AC chemotherapy cycles.
External link. Leave this field empty. Biomarkers Prev. Error bars indicate the standard error of the mean. Per experiment we used 1,, cells or more when available. And if you have digestive issues that are aggravated by greatly changing up what you eat, you may need to think through the pros and cons and have a conversation with your doctor. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. Additional information Peer review information Nature Communications thanks the anonymous reviewer s for their contribution to the peer review of this work. Abbreviations: FMD: fasting mimicking diet.
Some early findings also indicate that fasting could provide mice with more resistance to viral infection itself. Earlier trials of the fasting-mimicking diet reduced cardiovascular disease risk factors, including blood pressure and signs of inflammation measured by C-reactive protein levels, as well as fasting glucose and reduced levels of IGF-1, a hormone that affects metabolism. It also shrank waistlines and resulted in weight loss, both in total body fat and trunk fat, but not in muscle mass. In cancer patients, the fasting-mimicking diet appeared to sensitize cancer cells to chemotherapy and lessen treatment side effects. Trial participants on the special diet were required to eat food products supplied by the nutrition company L-Nutra during fasting periods of just five days each month. The diet, which was designed to mimic the results of a water-only fast, allowed for participants to consume between and 1, calories per day. The meals for the fast-mimicking diet contained precise proportions of proteins, fats and carbohydrates.